HORDB

ID: hor003330
Uniprot ID: P01212
Protein name: Met-enkephalin-Arg-Gly-Tyr
Gene name: penk-a
Organism: Xenopus laevis (African clawed frog)
Family: Opioid neuropeptide precursor family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0001515 opioid peptide activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: YGGFMRGY
Length: 8(180-187)
Propeptide: MGLEARHCCMFLLVFASLSVEIRADCSKDCASCALHLGQQREINSLACTLECEGKLPSAKAWGTCKELLLLTKVDNVQDGEKYQDNNDSHYAAKKYGGFMKRYGGFMKKMDELYHAEPEEDDAGGEILAKNYGGFMKKEYDSDRDAADLLRELLATSGDPESSIYHDNNSETPGEINKRYGGFMRGYRRSTDLEDETSGIQKRYGGFMRRVGRPEWWEDYQKRYGGFMTRFTDSFLPSDEDGESYSKENPDMEKR
Signal peptide: MGLEARHCCMFLLVFASLSVEIRA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Enkephalin neuropeptides compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003330_AF2.pdb

hor003330_ESM.pdb

Mass:	107511	Formula:	C44H59N11O11S
Absent amino acids:	ACDEHIKLNPQSTVW	Common amino acids:	G
pI:	9.17	Basic residues:	1
Polar residues:	5	Hydrophobic residues:	1
Hydrophobicity:	-45	Boman Index:	-705
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	0
Instability Index:	-1708.75	Extinction Coefficient cystines:	2980
Absorbance 280nm:	425.71